Aldosterone (CAS 52-39-1) is a hydroxycorticosteroid hormone produced by the adrenal cortex. Due to its chemical structure, aldosterone belongs to the polycyclics and pregnenediones molecule classes. The natural synthesis of Aldosterone takes place exclusively in the outer region of the adrenal cortex, called “zona glomerulosa”, and begins with a reaction that converts cholesterol to pregnenolone and further to progesterone. The progesterone that results is then hydroxylated, yielding deoxycorticosterone, or DOC. The final steps in the synthesis of this hormone involve the conversion of DOC into corticosterone, followed by two oxidation reactions. The production of aldosterone only begins after the body receives stimuli. The main stimulus that initiates the production process is a compound called angiotensin II. Other stimuli include high blood levels of potassium (hyperkalemia) or low levels of sodium (hyponatremia), as well as ACTH, serotonin, and endothelin.

Labeled AldosteroneThe importance of aldosterone derives from its involvement in the sodium and potassium balance. The mineralocorticoid hormone enhances the reabsorption of sodium and water and the release of potassium, thus being considered the “salt-retaining hormone”. It also enhances the reabsorption of the chloride ion along with sodium, ensuring that the body’s electrochemical balance is maintained. An aldosterone level that is higher than normal leads to low levels of potassium and increased blood pressure. An abnormally low level of aldosterone is also undesirable, as it can cause low blood pressure and an elevated pulse, symptoms that become more unpleasant while the individual is standing. Other symptoms of low aldosterone include posture-induced dizziness, palpitations, and salt-cravings. In severe cases, the levels of sodium and potassium will appear abnormal on the blood tests.

Aldosterone levels are low in patients who suffer from Addison’s disease and higher than normal in patients that have Conn’s syndrome. Other conditions that are related to abnormal levels of aldosterone include congenital adrenal hyperplasia, hyporeninemic hypoaldosteronism, primary or secondary hyperaldosteronism, and Bartter’s syndrome. In some cases, an abnormal blood level of aldosterone may be caused by extreme diets that are either very high or very low in sodium. It can also indicate kidney or liver disease, heart failure, or preeclampsia.

Most aldosterone blood tests now utilize a mass spectrometry based technique to determine the overall aldosterone level. As such IsoSciences offers an unlabeled form and two labeled forms of aldosterone – d4 and a d7.

5093UNL Aldosterone (unlabeled)

5093 Aldosterone (d7)

11214 Aldosterone (d4)

We are proud to offer a selection of stable labeled hormones. For your convenience, we sell unlabeled hormones alongside our list of labeled hormones. Our selection includes CertiMass™ Reference Standards, which are standard solutions for many of our premier compounds

If you are unable to find the desired hormone in our catalog, please contact us by email or phone (610-337-3762) we will be more than happy to provide a quote on custom synthetic work.